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Team FET:US
The Team
Background
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DiNP is the main plasticizer found in polyvinyl chloride (PVC) goods used to increase durability and flexibility in plastic goods. It has served as a supposedly safer alternative to previous plasticizers.
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However, research has shown that DiNP acts as an endocrine disrupting chemical impacting placental development, thus affecting maternal and fetal health.
Research
Research Question: How does DiNP affect placental and fetal development, and what are the underlying mechanisms behind it?
​Research Objectives:
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Determine the effects of varying levels of DiNP on placental cell lines
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​Develop a placental organoid comparable to primary tissue and in vivo models to investigate the effects of DiNP on placental development
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